This accredited CME activity describes a case study of a patient with a history of multiple comorbidities. He presents for evaluation for his persistent atrial fibrillation, and the clinical scenario unfolds to indicate that he had undergone various medical treatments and surgical procedures for his health issues. This is followed by a case-related question on his atrial fibrillation and brief answer explanations. Detailed case analysis and commentary, substantiated with supporting literature on the case study, are also provided to reinforce learning concepts.